갈색세포종과 복부 부신경절종의 임상적 특성 분석

• 영문명: Clinical Analysis of Pheochromocytoma and Abdominal Paragangliomas
• 발행기관: 대한내분비외과학회
• 저자명: 김상훈 정승필 이정희 김지영 최민영 이세경 최준호 이정언 김지수 남석진 양정현¹ 김정한 Sang-Hoon Kim M.D. Seung-Pil Jung M.D. Jeong-Hee Lee M.D. Ji-Yeong Kim M.D. Min-Yeong Choi M.D. Se-Kyung Lee M.D. Jun-Ho Choe M.D. Jeong-Eon Lee M.D. Jee Soo Kim M.D. Seok-Jin Nam M.D. Jung-Hyun Yang M.D.¹ and Jung-Han Kim M.D.
• 간행물 정보: 『The Koreran journal of Endocrine Surgery』11권4호, 269~275쪽, 전체 7쪽
• 주제분류: 의약학 > 면역학
• 파일형태: PDF
• 발행일자: 2011.12.30

영문 초록

Purpose: We compared clinical characteristics between pheochromocytoma and abdominal paragangliomas and identified predictive factors of malignancy. Methods: Between November, 1995 and January, 2011, we retrospectively reviewed the medical records of 145 patients with pheochromocytoma and abdominal paraganglioma at Samsung Medical Center. We compared two tumors (pheochromocytoma vs abdominal paraganglioma) about a potential of hypersecretion of cathecholamines and identified predictive factors of malignancy by analysis of clinical characteristics, biochemical markers, tumor features. Their postoperative results were also evaluated. Results: This study included 103 (71%) pheochromocytomas and 42 (29%) abdominal paragangliomas. Eighty-six percent were benign and 14% were malignant. Patients with paraganglioma were more predominantly men and exhibited a higher malignancy rate (P＜0.01) than pheochromocytoma patients. Most (95%) pheochromocytoma was hyperfunctional, but abdominal paraganglioma were hyperfunctional in 74%. There were no significant differences in biochemical markers between the pheochromocytoma and paraganglioma groupd. When compared with benign tumor, malignant tumors were significantly related with higher mean PASS (P＜0.01) and higher 24-hour urinary VMA (P=0.02), but not with larger tumor size. Conclusion: It is not easy to distinguish malignant from benign tumors by clinical characteristics and pathologic features in the management of pheochromocytoma and paraganglioma. We should keep in mind that abdominal paraganglioma can be also hyperfunctional in many pheochromocytoma patients and has a higher risk of malignancy. (Korean J Endocrine Surg 2011;11:269-275)

키워드

부신, 악성 갈색세포종, 부신경절종,Adrenal gland, Malignant pheochromocytoma, Paraganglioma