13C 및 15N 안정성 동위원소 비율 분석에 의한 원료의약품에서 에페드린 및 슈도에페드린의 기원 판별

• 영문명: Discrimination of the Origin of Ephedrine and Pseudoephedrine for Pharmaceutical Powder Materials by Carbon and Nitrogen Stable Isotope Ratio Analysis
• 발행기관: 대한약학회
• 저자명: 백승경(SeungKyung Baeck) Tetsuo Nagano 최화경(HwaKyung Choi) 정희선(HeeSun Chung) 표명윤(MyungYun Pyo) 정진일(JinIl Jeong) 양원경(Wonkyang Yang) Yukiko Makino 장문희(MoonHee Jang)
• 간행물 정보: 『약학회지』제53권 제5호 (2009년), 293~297쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.10.31

영문 초록

The abuse of methamphetamine (MA) is one of the most serious drug abuses in Asia. And, the prevention of precursor production for abuse drug is one of the most effective drug control system. Isotope ratio analysis at natural abundance levels have been used to establish the environmental source or the geographic origin of various biological and nonbiological materials. Ephedrine, the precursor of MA, is produced by one of three methods; extraction from Ephedra plants, full chemical synthesis or via a semi-synthetic process involving the fermentation of sugar, followed by amination. We investigated the origin of ephedrine and pseudoephedrine based on the carbon and nitrogen values for nineteen pharmaceutical powder materials (PPMs) obtained from pharmaceutical company in Korea by stable isotope ratio mass spectrometry coupled to an elemental analyser (EA-IRMS). The carbon delta values for the ephedrine and pseudoephedrine were -24.21~-22.72 (mean=-23.72) ‰ and -23.79~-22.71 (mean=-23.48) ‰. The nitrogen delta values were 3.51~5.55 (4.43) ‰ and 2.24~8.22 (5.42) ‰. These results indicate that PPMs are semi-synthetic products. Therefore the origins of ephedrine (natural, semi-synthetic or synthetic) could be discriminated by using carbon and nitrogen stable isotope ratios. we are sure tat this stable isotope ratio analysis can discriminate the origins of precursors of methamphetamine.

키워드

ephedrine pseudoephedrine precursor methamphetamine stable isotope ratio