KCl과 phenylephrine에 의한 대동맥 수축에서 Ca2+ 길항제와 protein kinase 억제제들의 비교 효과

• 영문명: Comparative Effects of Ca2+ Antagonists and Protein Kinase Unhibitors on Rat Aorta Contraction Induced by KCl and Phenylephrine
• 발행기관: 대한약학회
• 저자명: 심상수(Sang Soo Sim) 문성원(Sung Won Moon) 이윤혜(Yun Hye Lee) 이정근(Jung Keun Lee) 김현준(Hyun Jun Kim) 박진형(Jin Hyoung Park) 이준한(June Han Lee) 조중형(Jung Hyung Cho) 김창종(Chang Jong Kim)
• 간행물 정보: 『약학회지』제43권 제5호 (1999년), 659~664쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.10.28

영문 초록

To investigate the difference of contractile mechanism between KCl and phenylephrine-induced contraction, we observed effects of Ca2+ antagonists and protein kinase inhibitors on aorta contraction of rats. Verapamil dose-dependently inhibited the contraction induced by KCl and pheylephrine, the inhibitory effect of verapamil was more potent in KCl-induced contraction than phenylephrine-induced contraction. Econazole and TMB-8 significantly inhibited KCl-induced contraction but did not inhibit phenylephrine-induced contraction. Staurosporine dose-dependently inhibited both KCl and phenylephrine-induced contraction. Genistein and calmodulin antagonists (W-7 and trifluoperazine) also inhibited both contraction in a dose dependent manner. However, the inhibitory effects of genistein and calmodulin antagonists were more potent in pheylephrine-induced contraction than KCl-induced contraction. These results suggest that involvements of Ca2+ channel and protein kinase in rat aorta contraction were dependent on agonist causing aort smooth muscle contraction.

키워드

Aorta contraction calcium antagonists protein kinase inhibitor.