오미자에서 분리한 새로운 Chitin Synthase Ⅱ 저해제인 Gomisin N 과 Wuweizisu C

• 영문명: Gomisin N and Wuweizisu C, new Inhibitors for Chitin Systhase Ⅱ from Schizandra chinensis
• 발행기관: 대한약학회
• 저자명: 황의일(Eui Il Hwang) 김미경(Mi Kyung Kim) 이향복(Hyang Bok Lee) 김영국(Young Kook Kim) 권병목(Byoung Mog Kwon) 배기환(Ki Hwan Bae) 김성욱(Sung Uk Kim)
• 간행물 정보: 『약학회지』제43권 제4호 (1999년), 509~515쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1999.08.28

영문 초록

To search for new chitin biosynthesis inhibitors from natural sources, several higher plants were examined the inhibitory activity against chitin synthase Ⅱ by enzymatic assay. Among them, the extract of Schizandra chinensis strongly showed the inhibitory activity against chitin synthase Ⅱ. Gomisin N and wuweizisu C were isolated from Schizandra chinensis and showed IC50 value of 62.4mcg/ml and 19.2mcg/ml, respectively. Activities of these compounds were more stronger than that of polyoxin D. However, gomisin N and wuweizisu C showed weakly antifungal activities against various human pathogens.

키워드

Antifungal agents chitin synthase Ⅱ Schizandra chinensis gomisin N wuweizisu C polyoxin D.