db/db 마우스에서 상엽 에탄올가용분획의 항당뇨활성

• 영문명: Antidiabetic Activity of Mori Folium Ethanol Soluble Fraction in db/db mice
• 발행기관: 대한약학회
• 저자명: 류정화(Jeong Wha Ryu) 서성훈(Seong Hoon Seo) 정성현(Sung Hyun Chung)
• 간행물 정보: 『약학회지』제42권 제6호 (1998년), 613~620쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1998.12.31

영문 초록

Antidiabetic activity of Mori folium ethanol soluble fraction (MFESF) was examined in db/db mice, which is a spontaneously hyperglycemic, hyperinsulinemic and obese animal model. 500 and 1000mg/kg dose for MFFSF (designated by SY 500 and SY 1000, respectively) and 5mg/kg dose for acarbose were administered for 6 weeks. Body weight gain, fasting and non-fasting serum glucose, glycated hemoglobin and triglyceride were all reduced dose dependently when compared between db/db control group and MFESF treated group. At 11th and 13th week after birth, MFESF increased an insulin secretion which may result in lowering serum glucose level. Total activities of sucrase and maltase in SY 500 treated group were decreased when compared to db/db control. On the other hand, those in SY 1000 and acarbose treated groups were increased. This result may suggest that proteins for sucrase and maltase were compensatorily induced due to significant inhibition of glycosidase-catalyzed reaction at doses administered in this study.

키워드

Mori folium db/db mouse glycated hemoglobin triglyceride insulin sucrase maltase glycosidase.