Etomidoline과 Nefopam. HCl 병용투여시의 진경 및 진통 효과에 관한 연구

• 영문명: Antispasmodic and Analgesic Effects by Concurrent Administration of Etomidoline and Nefopam.HCl
• 발행기관: 대한약학회
• 저자명: 허인회(In Hoi Huh) 안형수(Hyung Soo Ann)
• 간행물 정보: 『약학회지』제25권 제1호 (1981년), 27~35쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.04.10

영문 초록

Etomidoline is a new synthetic atropine-like drug. The present investigation aimed to study the combined effects of etomidoline and neofopam hydrochloride which has an analgesic and muscle relaxant activity, compared with the effects of each drugs. Acute toxicities (ID50) in mouse were 132mg/Kg (p.o.)and 49mg/Kg (i.p.) when combination ratio of etomidoline and neofopam was 1:5 and 103mg/Kg (p.o.) and 30mg/Kg (i.p.) with the ratio of 1:10. Etomidoline showed more potent anticholinergic effects than neofopam in the isolated rat intestine. Whereas, antibarium effects were twice as active with neofopam than with etomidoline. When etomidoline and neofopam were added in combination ratio of 1:5, papaverine-like activity was increased, but no changes of anticholinergic effect were observed. Analgesic effect was measured by the anti-writhing method of Whittle in mice. Both of the concurrent and single administration of etomidoline and nefopam reduced significantly the writhing number and the effect of the concurrent administration was more active than that of single, and 1:5 combination was slightly more potent than 1:10. Each drug or the combined drug was administered to mice and observed the change of the pupil size. Pupil sizes were increased with each drug and with combined drug, although there were no significant differences between the each group of drugs. However, those effects were less than that of atropine sulfate.