우라자미드 정의 유해시약 대체 시험법의 개발

• 영문명: Development of Alternative Assay Method without Hazardous Reagent, Chloroform for Urazamide Tablets in Korean Pharmaceutical Codex
• 발행기관: 대한약학회
• 저자명: 이유림 김현지 서나래 김경호
• 간행물 정보: 『약학회지』제58권 제2호 (2014년), 125~128쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.30

영문 초록

We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets in Korean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accu-racy and robustness. The linearity of the calibration curves in the desired concentration range is good (r 2 >0.999). Precision was obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

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키워드

KPC hazardous reagents alternative methods validation HPLC