Effects of Agents with Antioxidant and Anti-inflammatory Properties on Preventing Memory Impairments due to Aging - From an In Vitro study to an in Vivo Animal Model

• 영문명: Effects of Agents with Antioxidant and Anti-inflammatory Properties on Preventing Memory Impairments due to Aging - From an In Vitro study to an in Vivo Animal Model
• 발행기관: 인제대학교 식품과학연구소
• 저자명: 한정수
• 간행물 정보: 『인제식품과학 FORUM 논총』제13회, 23~51쪽, 전체 29쪽
• 주제분류: 자연과학 > 생활/식품과학
• 파일형태: PDF
• 발행일자: 2006.04.01

영문 초록

  In the progression of neurodegeneration during the normal aging process, as well as in age-related neurological disorders such as Alzheimer"s disease (AD) and Parkinson"s disease (PD), the importance of glial cell-propagated inflammation (termed "neuroinflammation’) and oxidative stress has been highly appreciated and heightened interest in the rapid discovery of neuroinflammation- and oxidative stress-targeted therapeutics. Cognitive deficits due to aging and AD are also related to an increased vulnerability to oxidative stress and inflammation. However, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) for AD has largely failed due to gastrointestinal and occasional liver and kidney toxicity caused by cyclooxygenase (COX-1) inhibition. Therefore, interest has also been generated in searching for alternative natural anti-inflammatory agents that particularly target microglia-mediated neuroinflammation. We used in vitro assays to screen natural products that have a neuroprotective and antioxidative effect in the murine hippocampal cell line, as well as an anti-neuroinflammatory effect in primary and cultured microglia. We found some compounds isolated from natural medicinal plants and seaweed crude extracts that have both antioxidative and anti-inflammatory activities in murine neuron and microglia cells. We also present a chronic neuroinflammatory animal model accompanied with an impairment of the spatial learning memory to further screen antioxidative and anti-neuroinflammatory agents in vivo.

목차

Abstract
Introduction
Xanthorrhizol
Macelignan
Ulva conglobata
Neorhodomela aculeata
Chronic neuroinflammation animal model
Discussion
ACKNOWLEDGEMENTS
References

키워드

hippocampal neuron anti-inflammation oxidative stress iNOS COX-2 microglia glutamate interferon-γ