노인에서 망막층 두께와 뇌 백질 고강도 신호의 연관성 연구

• 영문명: Association Between Retinal Layer Thickness and Cerebral White Matter Hyperintensities in Older Adults
• 발행기관: 대한노인정신의학회
• 저자명: 김학현(Hak Hyeon Kim) 권민정(Min Jeong Kwon) 박지은(Jieun Park) 김준성(Jun Sung Kim) 김재형(Jae Hyoung Kim) 우세준(Se Joon Woo) 김기웅(Ki Woong Kim) 김형민(Hyeong Min Kim) 한지원(Ji Won Han)
• 간행물 정보: 『노인정신의학』제29권 제2호, 37~46쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.10.30

국문 초록

Objective: Retinal and cerebral small vessel changes may share common mechanisms in aging and neurodegeneration. We investigated the associations between macular retinal layer thickness and cerebral white matter hyperintensities (WMH) in older adults. Methods: We included 166 community-dwelling participants (mean age 75.2 years) from two population-based aging cohorts who underwent both spectral-domain optical coherence tomography and brain MRI. Retinal thickness was measured across six retinal layers in the macular region, the peripapillary retinal nerve fiber layers, and the subfoveal choroid. WMH volumes were classified into juxtaventricular (JVWMH), periventricular (PVWMH), and deep (DWMH) regions. Linear regression models adjusted for age, sex, hypertension, and diabetes were used to assess associations. Results: Outer macular ganglion cell layer (GCL) and inner plexiform layer (IPL) thicknesses were negatively associated with total WMH, PVWMH, and DWMH volumes. In contrast, foveal inner nuclear layer (INL) thickness showed a positive association with WMH burden. JVWMH volumes showed no significant association with most retinal layers. Conclusion: Outer GCL and IPL thickness was associated with lesser cerebral WMH volumes, while foveal INL thicknening suggests a distinct pathological process. These findings support potential retina-brain structural correlations and regional pathophysiological heterogeneity of cerebral white matter lesions.

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키워드

망막 백질연화증 빛간섭단층촬영 뇌소혈관질환 신경퇴행성 질환. Retina Leukoaraiosis Optical coherence tomography Cerebral small vessel disease Neurodegenerative diseases