유산균의 산성환경 적응 메커니즘: Two-Component System(TCS)과 γ-Aminobutyric Acid(GABA) 생산의 연계 가능성

• 영문명: Mechanisms of Lactic Acid Bacteria Adaptation to Acidic Environments: The Possible Interplay between Two-Component System (TCS) and γ-Aminobutyric Acid(GABA) Production
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: 황은영(Eunyeong Hwang) 박재용(Jae-Yong Park)
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』11권 1호, 10~22쪽, 전체 13쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

This review analyzes the mechanisms by which lactic acid bacteria (LAB) adapt to acidic environments, with a particular focus on the potential linkage between the two-component system (TCS) and γ-aminobutyric acid (GABA) production. LAB acidify their surroundings by producing lactic acid during fermentation, and as probiotics, they must also survive the highly acidic conditions of the human gastrointestinal tract. Consequently, they have developed sophisticated acid adaptation systems. At the molecular level, this review examines how LAB respond to acid stress, demonstrating that TCS plays a crucial role in sensing environmental signals and regulating gene expression accordingly. Additionally, the review explores the mechanisms through which GABA, produced as part of the acid stress response, contributes to acid tolerance. The findings suggest a potential connection between TCS signaling pathways and GABA production, which provides a fundamental basis for developing new strategies to enhance GABA production in LAB. From an industrial perspective, modulating TCS signaling could help optimize fermentation processes and improve probiotic viability. Furthermore, this review provides a theoretical basis for developing LAB strains with enhanced acid resistance and increased GABA productivity.

목차

서 론

산성환경 적응을 위한 유산균의 반응 메커니즘

유산균의 산성환경 적응 관련 연구

유산균의 GABA 생산과 산 저항 메커니즘

병원성균과 유산균에서 TCS와 GABA 생산 연계성 비교

결 론

References

키워드

lactic acid bacteria acid adaptation two-component system γ-aminobutyric acid