채혈 시간에 따른 부신피질 자극 호르몬 검사의 참고치 설정에 관한 고찰

• 영문명: Consideration for Setting Reference Range for Adrenocorticotropic Hormone Test according to Blood Collection Time
• 발행기관: 대한핵의학기술학회
• 저자명: 박지혜(Ji-Hye Park) 최진주(Jin-Ju Choi) 임수연(Soo-Yeon Lim) 유선희(Seon-Hee Yoo) 이선호(Sun-Ho Lee)
• 간행물 정보: 『핵의학기술』Vol.27 No.1, 47~52쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2023.05.30

영문 초록

Purpose: The reference range described in Adrenocorticotropic Hormone reagent used in our laboratory is 10-60 pg/mL at 8 a.m. to 10 a.m., and 6-30 pg/mL at 8 p.m. to 10 p.m. However, in the case of outpatients, blood is mainly collected between 10 a.m. and 6 p.m., accounting for 57.8% of the total. Therefore, This study is intended to help make a more accurate diagnosis by reevaluating the reference range provided by the manufacturer of the Adrenocorticotropic Hormone reagent and setting split-timed reference range. Materials and Methods: The patients collected blood before 10 a.m. were group A (68 people), and the patients collected blood after 10 a.m. were set to group B (80 people). A T-test was performed between groups to test their significance. And it was confirmed whether it was necessary to set the gender classification as a subgroup. The method of setting the reference range was calculated by the Bayesian’s method and the Hoffmann’s method. Results: The reference range of Group A was 8.6 to 60.6 pg/mL by the Bayesian’s method, and the Hoffmann’s method was 3.6 to 61.3 pg/mL. The reference range of Group B was 6.9 to 50.5 pg/mL when applying the Bayesian’s method, and the Hoffmann method’s was 2.3 to 48.9 pg/mL. Conclusion: This study was concluded that it was necessary to set the split-timed reference range. Through this study, the later the blood collection time, the lower the level of Adrenocorticotropic Hormone, indicating that blood collection time is important for patients with clinical significance. If a large number of subjects are selected and supplemented in the future, it is believed that systematic and accurate reference range can be set.

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실험재료 및 방법

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REFERENCES

키워드

Adrenocorticotropic Hormone T-Test Bayesian’s Method Hoffmann’s Method