Lactobacillus gasseri NK109 Alleviates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Up-Regulating Inflammation-Mediated BDNF Expression

• 영문명: Lactobacillus gasseri NK109 Alleviates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Up-Regulating Inflammation-Mediated BDNF Expression
• 발행기관: 한국유산균프로바이오틱스학회
• 저자명: Soo-Won Yun Hee-Seo Park Myung Joo Han Dong-Hyun Kim
• 간행물 정보: 『Current Topics in Lactic Acid Bacteria and Probiotics』9권 1호, 1~8쪽, 전체 8쪽
• 주제분류: 농수해양 > 식품과학
• 파일형태: PDF
• 발행일자: 2023.06.30

영문 초록

Exposure to lipopolysaccharide (LPS) causes cognitive impairment (CI). In the preliminary study, Lactobacillus gasseri NK109 suppressed LPS-induced expression of proinflammatory cytokines in macrophages. Therefore, the effect of NK109 on LPS-increased CI was investigated in mice. Intraperitoneal injection of LPS caused CI-like behaviors and neuroinflammation. However, orally administered NK109 reduced LPS-increased CI-like behaviors and hippocampal IL-1β and TNF-α expression, whereas LPS-decreased BDNF expression increased. NK109 also reduced LPS-increased colonic myeloperoxidase, IL-1β, and TNF-α expression. The efficacy of NK109 was increased by the combination of soybean embryo ethanol extract (SE). These findings suggest that NK109 with SE can improve CI by alleviating inflammation-mediated BDNF expression, thereby being beneficial for dementia therapy.

목차

INTRODUCTION

MATERIALS AND METHODS

RESUTLS

DISCUSSION

Funding

Conflicts of Interest

References

키워드

Lactobacillus gasseri NK109 cognitive impairment lipopolysaccharide