Effects of intermittent ladder-climbing training on neurobiological markers in mice with type 2 diabetes

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 신기옥(Ki-Ok, Shin) 우진희(Jinhee, Woo) 박찬호(Chan-Ho, Park) 윤병곤(Byung-Kon, Yoon) 김도연(Do-Yeon, Kim) 노희태(Hee-Tae, Roh)
• 간행물 정보: 『한국응용과학기술학회지』한국응용과학기술학회지 제37권 제4호, 762~768쪽, 전체 7쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2020.08.31

영문 초록

This study aimed to investigate the effect of ladder-climbing exercise training on neurobiological markers in the hippocampus of mice with type 2 diabetes (T2DM). Twenty-one C57BL/6 male mice were randomly assigned to the non-diabetic control (NDC, n = 7), diabetic control (DC, n = 7), and diabetic training (DT, n = 7) groups. The DT group performed ladder-climbing training (LCT) five times a week for eight weeks. We measured the levels of hippocampal neurobiological markers (catalase [CAT], brain-derived neurotrophic factor [BDNF], nerve growth factor [NGF], amyloid-beta [Aβ], tau, and CC motif chemokine ligand 11 [CCL11]). The BDNF levels were significantly higher in the DT group than in the DC group (p < 0.05). The Aβ and CCL11 levels were significantly higher in the DC group than in the NDC and DT groups (p < 0.05). The tau levels were significantly higher in the DC group than in the NDC group (p < 0.05). However, there was no significant difference in CAT and NGF levels among the groups (p > 0.05). These results suggest that while T2DM could induce neurodegeneration, LCT may be effective in alleviating neurodegeneration caused by T2DM.

목차

1. Introduction

2. Methods

3. Results

4. Discussion

5. Conclusion

References

키워드

resistance exercise neurotrophins neurogenesis neurodegeneration type 2 diabetes