The activation of PPAR-α and Wnt/β-catenin by Paeonia lactiflora root supercritical carbon dioxide extract

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Bora Kim
• 간행물 정보: 『한국응용과학기술학회지』한국응용과학기술학회지 제36권 제4호, 1136~1142쪽, 전체 7쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2019.12.30

영문 초록

The root of Paeonia lactiflora has been used in Chinese medicine. We conducted to check the comparative qualities of ethanol solvent extraction (PLE) and supercritical carbon dioxide extraction (PLS) of P. lactiflora root. PLE had higher antioxidant and polyphenol contents than PLS. But, PLS were significantly increased peroxisome proliferator-activated receptor (PPAR)-α. In addition, PLS inhibited the adipocyte differentiation of 3T3-L1 cells. When treated with the extract at a concentration of 100 μg/mL, the Wnt/β-catenin pathway reporter luciferase activity of HEK 293-TOP cells increased approximately by 3-folds compared to that of the untreated control group. These results indicate that P. lactiflora supercritical carbon dioxide extract may serve as a cosmeceutical for improving skin barrier function and the treatment of obesity.

목차

1. Introduction

2. Experimental

3. Results and Discussion

4. Conclusion

키워드

Paeonia lactiflora Supercritical carbon dioxide extraction Peroxisome proliferators activated receptors Wnt/β-catenin Adipocyte differentiation