Effect of resistance training at different intensities on hippocampal neurotrophic factors and peripheral CCL11 levels in obese mice

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Jinhee, Woo Hee-Tae, Roh Chan-Ho, Park Byung-Kon, Yoon Do-Yeon, Kim Ki-Ok, Shin
• 간행물 정보: 『한국응용과학기술학회지』한국응용과학기술학회지 제36권 제3호, 876~884쪽, 전체 9쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2019.09.30

영문 초록

We investigated the effect of moderate- and high-intensity resistance training on hippocampal neurotrophic factors and peripheral CCL11 levels in high-fat diet (HFD)-induced obese mice. C57/black male mice received a 4 weeks diet of normal (control, CON; n = 9) or a high-fat diet (HF; n = 27) to induce obesity. Thereafter, the HF group was subdivided equally into the HF, HF + moderate-intensity exercise (HFME), and HF + high-intensity exercise (HFHE) groups ( n = 9, respectively), and mice were subjected to ladder-climbing exercise for 8 weeks. The hippocampal brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) levels were significantly lower in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly higher than in the HF group ( p < 0.05). The peripheral CCL11 levels were significantly higher in the HF group than in the CON group ( p < 0.05). In addition, in the HFME and HFHE groups were significantly lower than in the HF group ( p < 0.05). However, there was no significant difference according to the exercise intensity among the groups. Collectively, these results suggest that obesity can induce down-regulation of neurotrophic factors and inhibition of neurogenesis. In contrast, regardless of exercise intensity, resistance training may have a positive effect on improving brain function by inducing increased expression of neurotrophic factors.

목차

1. Introduction

2. Methods

3. Results

4. Discussion

5. Conclusion

키워드

resistance training exercise intensity obesity neurotrophin eotaxin-1