Gross age-related changes and diseases in human heart valves

• 발행기관: 대한해부학회
• 저자명: Treerat Gumpangseth Pasuk Mahakkanukrauh Srijit Das
• 간행물 정보: 『Anatomy and Cell Biology』Vol.52(1), 25~33쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2019.03.30

영문 초록

Cardiac valves are highly complex structures optimizing their function during the cardiac cycle. They open and close directed by blood flow under different pressure conditions in the dynamic environment in the heart. It is acknowledged that the aging process affects the structure and functions of the heart valves. With regard to morphometry, age-related changes of the heart valve can be found in valve circumference, thickness of the leaflet, luminal area at the sinotubular junction, valve diameter, orifice area, and leaflet size in circumferential and radial direction. In addition, there are differences between male and female hearts in some features. Moreover, there are studies the qualitative and quantitative assessment of histological compositions, echocardiography study to investigate the annular circumference and diameter in the human heart valves related with age. Studies into the detailed anatomy of the changes in heart valves with age are important and the correlation between valve morphology and age may be used as an age indicator. This study reviews the basic anatomical structure of the heart valves, age-related changes of valve morphometry, heart valve diseases, and general treatment of valvular diseases in humans. Detailed knowledge of the anatomical features of the morphology of the human heart valve is useful for any treatments of valve pathology.

목차

Introduction

Anatomy of the Heart Valves

Tricuspid Valve

Mitral Valve

Pulmonary Valve

Aortic Valve

Heart Valves Morphometry Change with Age

Diseases Affecting Heart Valves

Rheumatic Valve Disease

Endocarditis

Treatment of Heart Valves Dysfunction

Future Direction

Conclusion

References

키워드

Tricuspid valve Mitral valve Pulmonary valve Aortic valve Age changes