The regulation of high-fat diet fed-induced obesity by fenofibrate and exercise

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Su mi Yu Kyuri Park Ji eun Kim Sun hyo Jeong
• 간행물 정보: 『한국유화학회 학술대회 논문집』2017년 추계학술대회, 143~143쪽, 전체 1쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2017.11.02

영문 초록

Fibrates are widely used hypolipidemic drugs, and regulate the expression of a number of genes that are critical for lipid metabolism, thereby leading to obesity. To determine whether anti-obesity action of fenofibrate is effectively regulated by exercise, mice were randomly divided into four groups. After they were treated with combinations of high-fat diet, fenofibrate or exercise for 8 weeks, determinants of obesity and lipid metabolism were measured. When mice were treated with fenofibrate or exercise, mice had significantly lower body weight, adipose tissue mass and serum lipid levels than control mice fed a high-fat diet alone. When mice were simultaneously treated with fenofibrate and exercise, exercise reduced even further the inhibitory effects of fenofibrate on body weight, adipose tissue mass and serum lipid levels. Also, exercise significantly decreased fenofibrate induced adipocyte size and hepatic lipid accumulation. This study suggests that the co-treatment of fenofibrate and exercise can effectively prevent obesity caused by ingestion of high-fat diet.

키워드

obesity fenofibrate exercise high-fat diet lipid metabolism