Synthesis of a New 4-(Pyridin-3-yl)pyrimidine Derivatives for Anticancer Activity

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Se Jin Jung Ibrahim Mustafa El-Deeb So Ha Lee
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제26권 제1호, 29~37쪽, 전체 9쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2009.03.31

영문 초록

This study is focused on the synthesis of urea and amide derivatives particularly, since the amide moiety is an essential binding group at the binding site. Urea derivatives 3-7 and 13-14 were obtained by reaction of 2-aminopyrimidines and other amines with diverse isocyanates in pyridine as a solvent under reflux. The urea derivatives were obtained in low yield because of the highly electron deficient nature of the amino group of the 2-aminopyrimidine. Amide derivatives 8-10 were obtained in moderate yields by reaction of compound 1 with aryl chloride derivatives. Also, arylamine 11 was synthesized by Buchwald-Hartwig amination in moderate yields. Most of the compound did not show good activity against A375P melanoma cells, compared with Sorafenib as control compound.

목차

Abstract

1. Introduction

2. Experimental

3. Results and Discussion

4. Conclusion

Acknowledgment

References

키워드

Anticancer activity 4-(pyridin-3-yl)pyrimidine derivatives A375P melanoma cells B-Raf