에멀젼 제형에서 수종의 폴리올이 방부 시스템에 미치는 영향

• 영문명: Effects of Various Polyols on Antiseptic System in Emulsions
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 조완구(Wan Goo Cho) 조영진(Young Jin Cho)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제25권 제4호, 477~484쪽, 전체 8쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2008.12.31

영문 초록

It is inevitable to use chemical germicidal agents like paraben, imidazolidinyl urea and phenoxyethanol to preserve the emulsions which is usually used in cosmetics. Although these chemical preservatives are good enough to reduce the microbiological contamination, they are irritative, allergenic to the skin. Several kinds of polyols are used in cosmetics as moisturizer and solvent. In this study, we evaluate the effects of polyols on anti-microbial activities, safety and resistant index. MIC(minimal inhibitory concentration) of polyols determined against 6 germs including Staphylococcus aureus. The order of MIC was PG DPG 1,3BG > HG > 1,2-PD > 1,2-HD 1,2-OD. The 2～3 wt% of 1,2-HD(hexanediol) shows good anti-microbial effects in emulsions without allergenic response. Resistant index of 1,2-HD was less than 2 and this value was smaller than that of chemical preservatives. The mechanism of antimicrobilogical effect might be disturb the membrane of germs by investigating using electron microscope. Added to that, using this paradigm, low preservative contents, paraben-free system, and even preservative-free systems can be expected from these results.

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감사의 글

참고문헌

키워드

polyol preservative emulsion cosmetic safety germicidal