1,3,4-Thiadiazole 유도체의 합성 및 Akt1 카이네이즈 저해 활성

• 영문명: Synthesis and Akt1 Kinase Inhibitory Activity of 1,3,4-Thiadiazole Derivatives
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 김세영(Se Young Kim) 류재천(Jae Chun Ryu) 유경호(Kyung Ho Yoo)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제25권 제3호, 370~379쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2008.09.30

영문 초록

Akt, a serine/threonine protein kinase as a viral oncogene, is a critical regulator of PI3K-mediated cell proliferation and survival. On translocation, Akt is phosphorylated and activated, ultimately resulting in stimulation of cell growth and survival. As a part of our program toward the novel Akt1 inhibitors with potent activity over PI3K signaling pathway, we found primary hit compound 2 with an IC50 value of 620 μM from protein kinase focused library. Based on the structural features of 2, new 1,3,4-thiadiazole derivatives were designed by the introduction of aromatic and heteroaromatic moieties onto thiadiazole nucleus. In this work, a series of 1,3,4-thiadiazole derivatives 1a-l were synthesized and evaluated for Akt1 inhibitory activity.

목차

1. 서 론

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3. 결과 및 고찰

4. 결 론

감사의 글

참고문헌

키워드

1,3,4-thiadiazoles synthesis Akt1 kinase inhibitory activity