고상법에 의한 Dermorphin 유사체의 합성과 생물학적 활성에 관한 연구

• 영문명: Synthesis of Dermorphin Analogues by the Solid Phase Method and Biological Activity
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 한만소(Han ManSo)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제19권 제4호, 281~290쪽, 전체 10쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2002.12.31

영문 초록

Dermorphin is a hepta peptide(H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-NH2 with exceptionally potent and long-lasting peripheral and central activity. Dermorphin analogues, dermorphionyl(DMP)-Lys-NH2 and DMP-Lys-Lys-NH2 have been prepared in order to examine the effect of opiod activity. Dermorphin analogues were synthesized by the solid phase method. The crude peptide was purified by gel filter on a Sephadex LH-20, characterized with HPLC and amino acid analyzer. Analgesic potency was estimated by writhing syndrome method and Randall-Selitto method. As a result, dermorphin analogues have lower potency than that of morphine.

키워드

dermorphin solid phase method writhing syndrome method Randall-Selitto method