β-Sitosterol이 HCT116 대장암세포의 콜로니형성 및 부착성에 미치는 효과

• 영문명: Effects of β-sitosterol on colony formation and adhesion in HCT116 human colon cancer cells
• 발행기관: 충북대학교 생활과학연구소
• 저자명: 송보람(Bo ram Song) 주지형(Ji hyeung Ju)
• 간행물 정보: 『생활과학연구논총』생활과학연구논총 제20권 제1호, 13~20쪽, 전체 8쪽
• 주제분류: 자연과학 > 생활/식품과학
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

β-Sitosterol is the most abundant phytosterol present ubiquitously in plants. The aim of the current study was to investigate the inhibitory effects of β-sitosterol on colony formation and adhesion in HCT116 human colon cancer cells. β-Sitosterol significantly inhibited cell growth (to 50-89% of the control by the concentrations of 25-100 μM; p<0.01) and effectively changed nuclear morphology (by the concentration of 50 μM) in HCT116 cells. These results confirm previous findings on the growth-inhibitory and apoptosis-inducing activities of β-sitosterol in different cancer cell lines. Treatment with β-sitosterol resulted in significant inhibition of both colony formation (to 29% of the control by the concentration of 50 μM) and adhesion (to 44-54% of the control by the concentration of 25-100 μM) in HCT116 cells. These results suggest that β -sitosterol might modulate the self-renewal capacity of colon cancer stem cells as well as invasion and metastasis during colon carcinogenesis. More in-depth studies are needed in order to verify such actions and to elucidate underlying mechanisms.

목차

Abstract

Ⅰ. 서론

Ⅱ. 재료 및 방법

Ⅲ. 결과 및 고찰

Ⅳ. 결론 및 제언

Ⅴ. 감사의 글

참고문헌

키워드

β-sitosterol colon cancer cell colony formation adhesion