Methidathion 중독사에 의한 사후혈액 및 조직중 분포

• 영문명: Postmortem Distribution of Methidathion in Human Specimens of a Acute Poisoning
• 발행기관: 대한약학회
• 저자명: 이종숙(Jong Sook Rhee) 이재신(Jae Sin Lee) 최동기(Dong Ki Choi) 양희진(Hee Jin Yang) 이상기(Sang Ki Lee) 구기서(Ki Ser Koo) 유영찬(Young Chan Yoo)
• 간행물 정보: 『약학회지』제46권 제2호 (2002년), 93~97쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.04.30

영문 초록

Methidathion is one of the organophosphorus pesticides commonly used for stamping out hanuul pests in farming areas. This paper presents a fatality due to methidathion intoxication and describes the distribution of methidathion in postmortem blood and tissues obtained at autopsy. Qualitative identification of methidathion was achieved by TLC, GC and GC/MS, and quantitative analysis was performed by GC with thermionic specific detector (TSD). The analytes in postmortem specimens were extracted by liquid- liquid extraction (LLE) with ethylether. After the ethylether layer was evap- orated, the residue was partitioned into hexane and acetonitrile, and the acetonitrile layer was used for analysis. Tissue specimens were homogenized with 4% perchloric acid and applied for LLE. After extraction, the extracts were reconstituted 100μg pyraclofos (IS,100μg/ml in methanol) for GC and GC/MS analysis. On analysis of Postmortem specimens, methidathion was identified and quantitated. The methidathion concentrations were 2.0μl/ml In blood,24.4μg/g in liver 13.9μg/g in lung, 21.8 μg/g in kidney respectively.

키워드

methidathion postmortem specimen GC GC/MS TLC.