Endothelial to mesenchymal transition: a central mechanism in diabetes-induced vascular pathology

• 발행기관: 대한생리학회-대한약리학회
• 저자명: Giang-Huong Vu Byeong Hwa Jeon Cuk-Seong Kim
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제29권 제6호, 699~711쪽, 전체 13쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.11.30

국문 초록

Diabetes mellitus is a major global health concern associated with microand macrovascular complications. Among the diverse mechanisms that contribute to vascular dysfunction in diabetes, endothelial to mesenchymal transition (EndMT) has emerged as a key pathological process. EndMT involves the loss of endothelial cell characteristics and the acquisition of mesenchymal features, resulting in impaired endothelial function, increased fibrosis, and inflammation. In addition to findings from preclinical models, recent human studies support the clinical relevance of End-MT. This review summarizes the molecular mechanisms governing EndMT, including key signaling pathways such as TGF-β, Notch, and Wnt, and examines how environmental, metabolic, and inflammatory cues influence this process. Furthermore, we discuss the maladaptive role of EndMT in diabetic complications, including nephropathy, retinopathy, atherosclerosis, and impaired wound healing, highlighting recent advances in anti-EndMT therapies and the clinical implications. Understanding the mechanisms of EndMT in the diabetic milieu may reveal novel therapeutic targets for preventing or reversing diabetic vascular diseases.

목차

INTRODUCTION

ENDOTHELIAL TO MESENCHYMAL TRANSITION

MECHANISMS

GENERAL INITIATING FACTORS

MALADAPTIVE ENDOTHELIAL TO MESENCHYMAL TRANSITION IN DIABETIC VASCULAR DISEASES

THERAPEUTIC TARGETING ENDOTHELIAL TO MESENCHYMAL TRANSITION IN DIABETIC VASCULAR COMPLICATIONS

CONCLUSION

FUNDING

ACKNOWLEDGEMENTS

CONFLICTS OF INTEREST

REFERENCES

키워드

Diabetes mellitus Diabetic vascular complications Endothelial dysfunction Endothelial-mesenchymal transition