Histological response of the periodontal tissue to mandibular incisor movement using clear aligners of varying thickness in a rabbit model

• 발행기관: 대한치과교정학회
• 저자명: Yue Wang He Liu Yueming Li Liwen Zhang Xun Yan Ruoxi Liu Xiao Shen Baohua Xu Qiang Sun
• 간행물 정보: 『The Korean Journal of Orthodontics』제55권 제5호, 405~417쪽, 전체 13쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

Objective: Investigate the histological response of the periodontal tissue to incisor movement using varying-thickness clear aligners in a rabbit model. Methods: Thirty-three New Zealand rabbits were randomly assigned to two experimental groups (0.38-mm and 0.68-mm aligners) and a control group. Each rabbit in the experimental group wore three sequential aligners, which were changed every 5 days. Orthodontic force was measured using a uniaxial force sensor, and tooth movement was quantified using three-dimensional imaging. Root resorption was assessed using micro-computed tomography. Histological and immunohistochemical staining and real-time quantitative reverse transcription polymerase chain reaction tests were performed to evaluate the periodontal tissue response. Results: The 0.68-mm aligners generated larger forces than the 0.38-mm aligners. Tooth movement was faster with the third 0.38-mm aligner, with no statistically significant differences between the two groups. Both groups exhibited minor root resorption, with the 0.68-mm group exhibiting larger resorption craters. Additionally, the 0.68-mm group demonstrated more significant deformation of periodontal fibers and increased expression of inflammatory markers. The 0.38-mm group showed a larger number of osteoclasts on the compression side. Conclusions: Both aligners achieved effective tooth movement. The 0.38-mm aligners exerted smaller forces and enabled slightly faster movements than the 0.68-mm aligners. Although both groups showed minimal root resorption, the 0.68-mm group exhibited larger resorption craters. Furthermore, the 0.38-mm group exhibited less histological deformation and inflammation in the periodontal tissues. These results suggest that aligner thickness can be tailored to customize treatments. Further studies with longer observation periods and more refined methodologies are warranted.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

CONCLUSIONS

References

키워드

Clear aligners Sheet thickness Histological changes Animal study