Increase of α-Synuclein in the Peripheral Blood of Subjects with Methamphetamine Use Disorder

• 발행기관: 대한신경정신의학회
• 저자명: Mi Ran Choi Younghoon Chon Joongbum Cho Changwoo Han Yeung-Bae Jin Sang-Rae Lee Dai-Jin Kim
• 간행물 정보: 『Psychiatry Investigation』제22권 제7호, 786~795쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.07.15

국문 초록

Objective Methamphetamine (MA) use has created significant public health problems worldwide. Its chronic abuse causes neurotoxicity resulting in disruption of neural plasticity and early onset of neurodegenerative diseases. Therefore, there is need for a biomarker to evaluate the neurotoxicity caused by MA. This study investigates the expression levels of α-synuclein (α-Syn), brain-derived neurotrophic factor (BDNF), and neuron-specific enolase (NSE) in the blood of patients with MA use disorder to identify potential biomarkers. Methods We collected blood samples from 60 subjects (30 normal healthy controls and 30 patients with MA use disorder [MA group]). We used multiplex assay kits to analyze the expression levels of α-Syn, BDNF, and NSE in the blood of these subjects. Results Beck Depression Inventory and Beck Anxiety Inventory scale scores were significantly different between the control and MA groups. The expression level of α-Syn in the MA group was significantly increased compared to that in the control group (z value=-1.986, p=0.0473). In contrast, BDNF in the MA group tended to increase as the duration of MA use increased (r=0.323, p=0.082). Conclusion We identified an increase of α-Syn in the blood of the MA group. This finding suggests that the α-Syn level increases in the brain after exposure to MA by passing through the blood brain barrier. This result provides useful information for potential biomarkers in diagnosis of neurodegenerative diseases caused by MA abuse.

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INTRODUCTION

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RESULTS

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키워드

Addiction Methamphetamine Neurotoxicity Alpha-synuclein