Changes in Heart Rate Variability in Adolescent Patients With Tic Disorders: A 1-Year Prospective Study

• 발행기관: 대한신경정신의학회
• 저자명: Hyeju Lee Nahyung Lee Yeje Lim June Christoph Kang Jeong-An Gim Moon-Soo Lee
• 간행물 정보: 『Psychiatry Investigation』제22권 제7호, 766~774쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.07.15

국문 초록

Objective This longitudinal study examined the impact of tic disorders on autonomic nervous system function using heart rate variability (HRV) as a biomarker and assessed its association with quality of life over a 1-year period. Methods The patient group comprised 39 individuals, of whom 19 were followed up after 1 year, whereas the control group included 30 individuals. Tic severity and quality of life were assessed using the Yale Global Tic Severity Scale and KIDSCREEN-27 questionnaire, respectively. HRV parameters were used to measure autonomic function during this period. Results At baseline, patients with tic disorders demonstrated lower HRV, particularly in low-frequency (LF) power, and a higher standard deviation of the average normal-to-normal intervals, indicating significant autonomic dysregulation compared to control participants. Over the 1-year follow-up period, these patients demonstrated a decline in HRV indices, particularly LF power. HRV metrics and quality of life scores exhibited significant correlations at baseline, indicating that a better autonomic balance status was associated with perceived better quality of life. During follow-up, the correlations between HRV measures and psychological/behavioral scales observed at baseline were altered and no longer significant, potentially reflecting the effects of treatment and homeostatic adaptation over time. Conclusion Tic disorders are associated with persistent autonomic dysfunction, which progressively impair physiological regulation and quality of life. The findings of this study elucidate the significance of incorporating strategies for autonomic modulation into treatment plans for patients with tic disorders.

목차

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

키워드

Tic disorders Heart rate variability Quality of life Stress Longitudinal study