Importance of mitochondrial quality control and its role in pathophysiology

• 영문명: Importance of mitochondrial quality control and its role in pathophysiology
• 발행기관: 조선대학교 의학연구원
• 저자명: Sang-Hun Kim Seon-Hee Oh
• 간행물 정보: 『Medical Biological Science and Engineering』제6권 제1호, 8~13쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.01.31

영문 초록

Mitochondria are essential cell organelles that sustain life in multicellular organisms, from primitive organisms to highly differentiated mammals. They play critical roles in survival including energy production via oxidative phosphorylation, regulation of apoptosis, and calcium and reactive oxygen species signaling. Mitochondrial quality control mechanisms, including fission, fusion, and mitophagy, are thus critical for maintaining mitochondrial function, and their impairment causes many human diseases, including neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease, metabolic disorders, and cancer. Mitochondrial dynamics are maintained by balancing the functions of guanosine triphosphatase family proteins including fission proteins (dynamin-related protein 1, mitochondrial fission 1 protein) and fusion proteins (mitofusin-1/2, a dynamin-related protein). In particular, significant roles of Drp1 in mitochondrial structure, distribution, and pathophysiology have been demonstrated in many studies. Mitophagy, the process of selective mitochondrial degradation by autophagy, plays an important role in maintaining cellular homeostasis by eliminating dysfunctional mitochondria. This review addresses the importance of mitochondrial quality control and its role in human pathophysiology. We also introduce our recent studies on mitophagy.

목차

INTRODUCTION

MITOCHONDRIAL QUALITY CONTROL THROUGH MITOCHONDRIAL GENES

MITOCHONDRIAL FRAGMENTATION AND PATHOGENESIS

MITOCHONDRIA QUALITY CONTROL THROUGH MITOPHAGY

ACKNOWLEDGMENTS

CONFLICT OF INTEREST

REFERENCES

키워드

Mitochondria Fission Fusion Quality control Mitophagy