Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue

• 영문명: Hyperbaric oxygenation applied before or after mild or hard stress: effects on the redox state in the muscle tissue
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Claudia Carolina Pérez-Castro Alexandre Kormanovski Gustavo Guevara-Balcázar
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제27권 제1호, 9~20쪽, 전체 12쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2023.01.31

영문 초록

The mechanism is unclear for the reported protective effect of hyperbaric oxygen preconditioning against oxidative stress in tissues, and the distinct effects of hyperbaric oxygen applied after stress. The trained mice were divided into three groups: the control, hyperbaric oxygenation preconditioning, and hyperbaric oxygenation applied after mild (fasting) or hard (prolonged exercise) stress. After preconditioning, we observed a decrease in basal levels of nitric oxide, tetrahydrobiopterin, and catalase despite the drastic increase in inducible and endothelial nitric oxide synthases. Moreover, the basal levels of glutathione, related enzymes, and nitrosative stress only increased in the preconditioning group. The control and preconditioning groups showed a similar mild stress response of the endothelial and neuronal nitric oxide synthases. At the same time, the activity of all nitric oxide synthase, glutathione (GSH) in muscle, declined in the experimental groups but increased in control during hard stress. The results suggested that hyperbaric oxygen preconditioning provoked uncoupling of nitric oxide synthases and the elevated levels of GSH in muscle during this study, while hyperbaric oxygen applied after stress showed a lower level of GSH but higher recovery post-exercise levels in the majority of antioxidant enzymes. We discuss the possible mechanisms of the redox response and the role of the nitric oxide in this process

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키워드

Glutathione Hyperbaric oxygen Mice Nitric oxide Nitic oxide synthase Stress