Immunomodulatory and Energy-Enhancing Effects of Modified SOUL-tang

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Kyung-Min Jeong Yu-Jin Choi Hyun-Ja Jeong
• 간행물 정보: 『셀메드』Volume 15 Issue 6, 1~6쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2025.05.31

국문 초록

Modified SOUL-tang (MST) has been known to improve recovery of energy, regulation of body heat, and improvement of qi circulation, but the scientific evidence of MST has not been established. Here, we aimed to determine the energy-regulating effect of MST on performance in the forced swimming test (FST) and on RAW264.7 macrophage activity. MST was administered orally once a day for 28 days. On the 28 days, the immobility time in the FST was significantly decreased in the MST-fed group in comparison with the control group. MST induced a significant increase in serum interferon-γ, interlukin-2, and tumor necrosis factor (TNF)-α levels compared with the control group. In vitro experiments demonstrated that MST significantly increased the expression of TNF-α, nitric oxide (NO), and inducible NO synthase in RAW264.7 macrophages. Furthermore, MST stimulation induced the phosphorylation of IκBα, subsequently promoting the nuclear translocation of nuclear factor-κB. These results indicate that MST enhances energy by boosting immune function, suggesting its potential as an energizer for individuals with energy deficiency.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULT

DISCUSSION

ACKNOWLEDGEMENT

RESEARCH FUNDING

CONFLICT OF INTEREST

REFERENCES

키워드

MST FST interferon-γ nitric oxide nuclear factor-κB