수면호흡장애와 대 사적 기능장애

• 영문명: Sleep-Disordered Breathing and Metabolic Dysfunction
• 발행기관: 대한수면의학회
• 저자명: 주순재(Soonjae Joo) 신철(Chol Shin)
• 간행물 정보: 『수면정신생리』제12권 제1호, 17~22쪽, 전체 6쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

Sleep-disordered breathing (SDB) is associated with increased cardiovascular and cerebrovascular morbidity. Epidemiological and clinic-based studies have shown that SDB is related to impaired glucose tolerance and increased insulin resistance, independent of obesity. Despite of a consistent association between SDB and impaired glucose-insulin metabolism, the mechanism underlying this relationship has not been fully elucidated. It is recognized that hypoxemia and hypercapnia that occur in SDB provoke sympathetic nervous activity and catecholamine, epinephrine and norepinephrine, and cortisol are released. Sympathetic hyperactivity and increased catecholamines can impair glucose homeostasis by increasing glycogenolysis and gluconeogenesis, which can result in increased circulating insulin levels and increased risk of insulin resistance. A prospective study is needed to investigate the causal relationship between SDB and impaired glucose-insulin metabolism in a healthy population without diabetes, hypertension and obesity as etiologic risk factors.

목차

서 론

본 론

결 론

키워드

수면호흡장애 내당능 인슐린 저항성 Glucose tolerance Insulin resistance Sleep disorders