Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function

• 영문명: Developmental Disability Animal Model Based on Neonatal Lipopolysaccharide with Altered 5-HT Function
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jae Goo Kim Min Soo Kim Seoul Lee Gun Tae Kim Jong Doo Lee Dong Goo Kim
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제11권 제3호, 113~119쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2007.01.01

영문 초록

Developmental disability shows life-long behavioral abnormality with no significant physical malformation. This study was undertaken to develop an animal model for developmental disability by using two-factor approach. Lipopolysaccharide (LPS), a bacterial toxin, and NAN-190, a 5-HT1A receptor antagonist, were administered to Sprague-Dawley rats on postnatal day (PND) 5 to induce inflammation and an altered 5-HT system, respectively. Long-term alteration of behavior occurred in the drug-treated groups. The LPS-treated group showed impaired motor coordination in the Rota-rod test. The LPS- treated or both LPS and NAN-190-treated groups showed impaired fore-paw muscle power in the wire maneuver test. These groups also showed decreased white matter volume and increased serotonergic fibers. The LPS and NAN-190-treated group also exhibited neurologic deficit in the placing reaction test and impaired equilibrium function in the tilt table test. The results showed that a variety of altered behaviors can be generated by two factor model, and suggested that combination of important etiologic factors and possible underlying defects is a promising strategy of establishing an animal model for developmental disabilities.

키워드

Developmental disability Lipopolysaccharide 5-HT1A receptor Animal model