Cocaine-induced Changes in Functional Connectivities between Simultaneously Recorded Single Neurons in the SI Cortex and the VPL Thalamus of Conscious Rats

• 영문명: Cocaine-induced Changes in Functional Connectivities between Simultaneously Recorded Single Neurons in the SI Cortex and the VPL Thalamus of Conscious Rats
• 발행기관: 대한생리학회
• 저자명: Shin, Hyung-Cheul Park, Hyoung-Jin Oh, Yang-Seok Chapin, John K.
• 간행물 정보: 『대한생리학회지』제27권 제1호, 79~92쪽, 전체 14쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

The present study was carried out to determine the effects of cocaine (0.25, 1.0, 10.0 mg/kg, i.p.) on the interactions between spontaneously active neurons within ensembles of simultaneously recorded neurons in the primary somatosensory cortex (Sl, n= 20) and the ventroposterolateral (VPL, n= 16) thalamic nucleus of awake rats. Spike triggered cross correlation histograms were constructed between pairs of simultaneously recorded neurons. Among 101 neuronal pairs analyzed, 22.7% showed correlations indicative of various functional connections among the cortical cells, two corticothalamic interactions and one thalamocortical excitatory interaction. There were also 15 cofiring activities among SI cortical cells. These functional connectivities appeared to be modulated (weakened, abolished, or strengthened) during the 5 to 30 min following cocaine injection. The effects of saline were tested as a control, but it did not appear to alter the functional connectivities. In general, cocaine-induced changes of the functional interactions were mainly due to the concomitant alterations of the uncorrelated background discharges. These results suggest that the biphasic effects of cocaine on the spontaneously established neural networks among the SI cortical and the VPL thalamic cells of conscious rat were mainly indirect. However, various changes of the functional interactions by different doses of cocaine appeared to be a possible neural network mechanism for the cocaine induced modulation of afferent somatosensory transmission.

키워드

Cocaine Somatosensory cortex VPL thalamus Functional connectivity Neural network