Both Nifedipine and Bay K 8644 Potentiate the Release of Atrial Natriuretic Peptide in Response to Volume Expansion

• 영문명: Both Nifedipine and Bay K 8644 Potentiate the Release of Atrial Natriuretic Peptide in Response to Volume Expansion
• 발행기관: 대한생리학회
• 저자명: Lee, Jong-Eun Koh, Cheon-Suk Yeum, Cheol-Ho
• 간행물 정보: 『대한생리학회지』제27권 제1호, 51~56쪽, 전체 6쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1993.06.30

영문 초록

The effects of a calcium channel blocker and an activator on the release of atrial natriuretic peptide (ANP) were investigated in rats. They were volume expanded (VE) up to 5% of the body weight over 30min by being infused with iso-oncotic saline. Following VE, plasma ANP concentration markedly increased in association with increases in the right atrial pressure. Addition of either nifedipine (0.4μm/min) or Bay K 8644 (0.4μm/min) in the infusate potentiated the VE-induced release, although neither of them affected the right atrial pressure. The nifedipine added group showed a lower mean arterial pressure than the Bay K added group throughout the infusion period. VE decreased plasma renin concentration, the magnitude of which was attenuated by nifedipine but not by Bay K. It may be hypothesized that a decrease in cytoplasmic calcium is primary stimulus far the ANP release, and an increase plays o role in secondary liberation of the ANP accumulated in the interstitium into the lumen of the atria through myocardial contraction. further studies will be needed to confirm the hypothesis.

키워드

Atrial natriuretic peptide Volume expansion Calcium Nifedipine Bay K 8644 Renin