Vasopressin의 멜라닌 확산작용에 대하여

• 영문명: Melanin-dispersing Effect of Vasopressin on Frog Skin Melanocyte
• 발행기관: 대한생리학회
• 저자명: 홍승길(Hong, Seung-Kil)
• 간행물 정보: 『대한생리학회지』제7권 제2호, 59~66쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1973.12.31

영문 초록

It has been reported that vasopressin disperse the melanophore granule of frog skin. The author used hypophysectomized and adrenergic receptor blockaded animals in order to define the mechanism of vasopressin on the melanopore pigment of frog skin. The Rana niglomaculata which could be found in the Seoul area were used on this experiment. The amount of the following drugs were injected into the lymphatic sac of the frog; vaospressin (0.05 μg/g B.W.), dibenzylin (0.05 μg/g B.W.), and propranolol (0.01 μg/g B.W.). The following results were observed; 1. Vasopressin dispersed the melanin granules of melanocyte of frog skin. 2. The melanin granule dispersion activity of vasopressin was observed on the hypophysectomized frog. 3. The melanin granule dispersion was observed on the adrenergic receptor blockaded frog with dibenzylin or propranolol respectively, especially the later one was found to be more obvious. 4. The melanin granule dispersion was observed on the frog which was injected with vasopressin after alpha-receptor or beta-receptor blockade and the later one was found to be more obvious. 5. The melanin granule dispersion was more effective with the blockade of beta-receptor after the treatment with vasopressin on hypophysectomized frog.