만성정신분열병의 양성 및 음성증상에 대한 Lithium의 항정신병 효과

• 영문명: Antipsychotic Effects of Lithium on Positive and Negative Symptoms of Chronic Schizophrenia
• 발행기관: 대한신경정신의학회
• 저자명: 성상경 장환일 김시균
• 간행물 정보: 『신경정신의학』제28권 제1호, 55~66쪽, 전체 12쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1989.01.31

영문 초록

The authors investigated the antipsychotic effect of lithium in 24 chronic refractory schizophrenics with special interest in it’ s effects on positive and negative symptoms by a method of placebo controlled double-blined cross-over study. Subjects were divided into two sequences : Sequence 1 was Base-Lithium(4wks) — Placebo(4wks) — Lithium(4wks), and Sequence 2 was Base- Placebo(4wks) — Lithium(4wks) - Placebo(4wks). 24 schizophronics, diagnosed according to DSM-III-R, were randomly assigned to each sequences so that each sequence had the same number of patients. SAPS (Scale for the assessment of positive symptoms) and SANS (Scale for the assessment of negative symptoms) were used for the assessment of the subjects’ s mental status. 1) 9 of 24 subjects(31 깠 ) belonged to lithium-responder group * and others to lithium nonresponder group. 2) In 9 lithium-responders, statistically significant improvement was noticed in “severity of hallucination” as positive symptom and in “alogia” as negative symptom. 3) “Clothing & appearnce” among positive symptoms and “inappropriate affect” and ^subjective complaint of inattentiveness” among negative symptoms changed statistically significantly in all subjects (N —24). All global ratings did not change significantly after lithium treatment.

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