폐절제술을 시행한 대장직장암의 폐전이 환자에서 예후예측인자와 생존율 분석

• 영문명: Pulmonary Resection for Metastases from colorectal Cancer: Prognostic Factors and Survival
• 발행기관: 개인저작물
• 저자명: 이루지(Loo J Yi) 이원석(Won-Suk Lee) 윤성현(Seong Hyeon Yun) 전호경(Ho-Kyung Chun) 이우용(Woo Yong Lee) 윤해란(Hae-Ran Yun) 김진국(Jhingook Kim) 김관민(Kwanmien Kim) 심영목(Young Mog Shim)
• 간행물 정보: 『개인저작물 - 의학』대한대장항문학회지 제23권 1호, 53~59쪽, 전체 7쪽
• 주제분류: 의약학 > 개인저작물
• 파일형태: PDF
• 발행일자: 2007.01.01

영문 초록

Pupose: Pulmonary metastases occur in up to 10% of all patients who undergo a curative resection for colorectal cancer. Surgical resection is an important part in the treatment of pulmonary metastasis from colorectal cancer. We analyzed the treatment outcome and the prognostic factors affecting survival in this subset of patients. Methods: Between a curative resection for pulmonary metastases from clorectal cancer. Uncontrollable synchronous liver and lung metastasis or synchronous colorectal cancers with isolated lung metastasis were excluded from this study. A retrospective review of the patients` characteristics and of factors influencing survival was performed. Survival was analyzed by using the Kaplan-Meier method. Comparisons between the groups were performed by using a log-rankanalysis and the Cox proportional hazard model. Results: The 5-year overall survival rate of all patients who received a pulmonary resection was 50.3%. The number of pulmonary metastases was significantly related with survival monary metastases was significantly related with survival(P=0.032). A pre-thoracotomy CEA level exceeding 5 ng/ml was related with poor survival(P=0.001). A disease-free interval of greater than 2 years did not correlate with survival after a thoracotomy (P=0.3). Conclusions: The pre-thoracotomy CEA level and the number of metastases were independent prognostic factors. Resection of a pulmonary metastasis from colorectal cancer may result in improved survival or even cure in selected patients. A pulmonary resection of colorectal cancer is regarded as a safe and effective treatment with low mobidity and mortality rates. J Korean Soc Coloproctol 2007;23;53-59

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키워드

Colorectal cancer metastases Surgery CEA Recurrence 대장직장암 폐전이 수술 암배아성항원 재발