비약물적 호흡기능 강화 중재의 폐기능 및 운동능력 개선 효과: COPD 및 COVID-19 대상 메타분석 연구

• 영문명: Meta-analysis of the Effects of Nonpharmacological Respiratory Interventions on Pulmonary Function and Exercise Capacity in Patients with COPD and COVID-19
• 발행기관: 대한심장호흡물리치료학회
• 저자명: 정대인(Dae-In Jung) 이한결(Han-Gyeol Lee)
• 간행물 정보: 『대한심장호흡물리치료학회지』제13권 제3호, 81~88쪽, 전체 8쪽
• 주제분류: 의약학 > 재활의학
• 파일형태: PDF
• 발행일자: 2025.11.30

국문 초록

Purpose: This meta-analysis aimed to evaluate the effectiveness of nonpharmacological respiratory interventions in patients with pulmonary diseases. Specifically, it quantitatively assessed the impact of these interventions on pulmonary function (forced expiratory volume in 1 s [FEV₁], forced vital capacity [FVC], maximal inspiratory pressure [MIP], and maximal expiratory pressure [MEP]) and exercise capacity (6-min walk test [6MWT]) based on randomized controlled trials (RCTs). Methods: A total of 129 RCTs published over the past 10 years were initially identified from PubMed, Embase, and Cochrane Library. After applying the eligibility criteria, four studies were included in the final analysis. The effect sizes were calculated using the standardized mean difference (SMD), and a random effects model was applied considering inter-study heterogeneity. Subgroup analyses were performed by disease type, intervention method, and functional outcomes. Results: Significant improvements were found across all outcomes (FEV₁: SMD=0.28; FVC: SMD=0.25; MIP: SMD=0.31; MEP: SMD=0.29; 6MWT: SMD=0.34; all p<.001). Inspiratory muscle training (IMT) showed the greatest effect size (SMD=0.36), and the most consistent improvement was observed in patients with chronic obstructive pulmonary disease (SMD=0.34). The results of funnel plot visualization and Egger’s test (p=.557) indicated a low risk of publication bias. Conclusion: Nonpharmacological respiratory interventions are effective in improving pulmonary function and exercise capacity in patients with pulmonary diseases. IMT, pulmonary rehabilitation, and combined training modalities demonstrated high clinical utility. Future research should focus on standardized intervention protocols, long-term follow-up, and tailored approaches for high-risk populations.

목차

Ⅰ. 서 론

Ⅱ. 연구 방법

Ⅲ. 연구결과

Ⅳ. 고 찰

Ⅴ. 결 론

참고문헌

키워드

pulmonary disease inspiratory muscle training pulmonary rehabilitation non-pharmacological intervention meta-analysis exercise capacity

참고문헌

• Medicina
• Chronic Respir Dis
• Phys Ther
• Respir Med
• ERJ open research
• Heliyon
• Biol Sport
• J Appl Physiol
• Scand J Med Sci Sports
• Arch Phys Med Rehabil
• Arch Bronconeumol
• Int J Chron Obstruct Pulmon Dis
• Int J Environ Res Public Health
• Am J Respir Crit Care Med