학술논문
A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis
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- 영문명
- 발행기관
- 대한해부학회
- 저자명
- Kyungsook Jung Deokho Ko Sungmoo Hong Irene Ortiz-Leal Pablo Sanchez-Quinteiro Meejung Ahn Changjong Moon Taeyoung Kang Taekyun Shin Jeongtae Kim
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.58(3), 483~488쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2025.09.30
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국문 초록
Inflammation of the vomeronasal organ (VNO) was evaluated in the context of experimental autoimmune encephalomyelitis (EAE). The VNO was sampled in mice with myelin oligodendrocyte glycoprotein-induced EAE, and processed for paraffin embedding. The sections were immunohistochemically evaluated for various markers, including ionized calcium binding adaptor molecule 1 (Iba1), myeloperoxidase (MPO), and olfactory marker protein (OMP). Inflammatory cell infiltration was detected in the connective tissues. Both Iba1-positive macrophages and MPO-positive neutrophils infiltrated the VNO of EAE, with increased secretion of mucus into the lumen. The intensity of the OMPpositive immunoreaction was decreased in the vomeronasal sensory epithelium of EAE-induced mice. We postulate that the inflammatory response of the VNO in EAE is associated with dysfunction of the accessory olfactory system.
영문 초록
목차
Introduction
Materials and Methods
Results
Discussion
ORCID
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References
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