학술논문
Protective effect of Chlorella vulgaris against experimental hepatic ischemia reperfusion injury downregulating oxidative stress, inflammation, and apoptosis
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- 영문명
- 발행기관
- 대한해부학회
- 저자명
- Amira E. Farage Mona A. Abdel-Kareem Medhat Taha Sara Abubakr Nora Elshehawy Helal Mahmoud Hendawy Hanan A. Elgendy Ahmed Abdel-monem Elmetwally Hala Mahfouz Tourki A. S. Baokbah Mohammed R. Rabei Mohammad Akbar Hossain Azza I. Helal Mohie Mahmoud Ibrahim
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.58(3), 460~472쪽, 전체 13쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2025.09.30
4,360원
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국문 초록
Hepatic ischemia/reperfusion (Hep I/R) is a great health burden during hepatic transplantation surgery. The present workaimed to examine the mitigative effect of Chlorella vulgaris against Hep I/R and its underlying protective mechanisms. The animals inthe present research were classified into four equal experimental groups (n=6): the sham group, sham+Chlorella vulgaris group, HepI/R group, and Hep I/R+Chlorella vulgaris group. Hepatic ischemia results in liver impairment, as evidenced by elevated liver enzymelevels and altered liver histology. It also reduced antioxidant enzyme levels and increased lipid peroxidation. Additionally, the Hep I/Rgroup displayed significant suppression of the nuclear factor erythroid 2-related factor 2 (Nrf2)/haem oxygenase-1 pathway. There was amarked elevation in the expression of inflammatory markers, including nuclear factor kappa beta (NF-κB), tumor necrosis factor-alpha,interleukin-1 beta, interleukin-6, and myloperoxidase, and NOD-like receptor protein 3 (NLRP3) and caspase-1. Furthermore, thelevels of apoptotic markers such as caspase-3 and Bax were greater than those in the sham groups. Pretreatment with Chlorella vulgarissignificantly protected against Hep I/R by reversing these effects. Rats pretreated with Chlorella vulgaris exhibited a hepatoprotectiveeffect against Hep I/R through its inhibition of the NF-κB and NLRP3 cascades and Nrf2 stimulation.
영문 초록
목차
Introduction
Materials and Methods
Results
Discussion
ORCID
Author Contributions
Conflicts of Interest
Funding
Acknowledgements
References
키워드
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