Effects of Fenbendazole on anti-inflammatory and immune molecule expression in RAW264.7 cells

• 발행기관: 한국예방수의학회
• 저자명: Dong-Ju Lee Hong-Gu Joo
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.49, No.3, 139~143쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

Fenbendazole (FBZ) is one of benzimidazole drugs, which is well known for its broad spectrum of anthelmintics. During recent research on FBZ, it is also expected to have anti-inflammatory characteristics. However, the related research on FBZ with its anti-inflammatory effects is still lacking. This study focuses on the effects of FBZ on macrophage cell line of mouse, RAW264.7, and also on the inflammatory condition induced by lipopolysaccharide (LPS). FBZ alone treatment on RAW264.7 cells reduced the metabolic activity on the range of 1-5 µM, but the metabolic activity in the presence of LPS was higher than that of absence of LPS. Given that LPS has the ability to enhance glucose uptake in macrophage and rapid ATP production, there is a possibility that LPS increases the metabolic activity. Whereas TNF-alpha was hardly produced at FBZ 1-5 µM in the presence of LPS, IL-10 was still being produced, suggesting on the possibility of anti-inflammatory effect. Interestingly, despite the decreased survival of cells treated with FBZ, MHC class II and CD86 expression in surviving cells was markedly increased. Further investigation of FBZ is required through in vivo experiments to validate these findings. Key words: Fenbendazole, lipopolysaccharide, mouse macrophage, RAW264.7 cells, anti-inflammatory effect

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Fenbendazole lipopolysaccharide mouse macrophage RAW264.7 cells anti-inflammatory effect