피부에서 히스톤 탈아세틸화효소(HDAC)의 생리적 기능과 병리적 역할

• 영문명: Physiologic and Pathological Roles of Histone Deacetylase (HDAC) in the Skin
• 발행기관: 대한약학회
• 저자명: 최지혜(Ji Hye Choi) 최연자(Yeon Ja Choi)
• 간행물 정보: 『약학회지』제69권 제3호(2025년), 224~232쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Histone deacetylases (HDACs) are key epigenetic regulators that control gene expression by modifying chromatin structure. In the skin, HDACs play an essential role in maintaining homeostasis and contribute to the pathogenesis of various skin diseases. Here, we provide a comprehensive review of the expression and function of HDACs in normal skin and their role in skin disorders such as fibrosis and psoriasis, providing new insights into their potential as therapeutic targets. In healthy skin, HDACs regulate epidermal stem cell maintenance, keratinocyte differentiation, skin barrier formation, hair follicle formation, sebocyte lipogenesis, and modulation of the immune response. In fibrosis, aberrant HDAC activity promotes fibroblast activation and enhances TGF-β signaling, leading to excessive collagen deposition. In wound healing, HDAC triggers inflammatory responses and inhibits keratinocyte migration. In inflammatory skin diseases, HDACs regulate the expression of inflammatory mediators such as MCP1 and induce immune cell infiltration and activation. In addition to these mechanistic insights, HDAC inhibitors such as TSA (trichostatin A), SAHA (suberoylanilide hydroxamic acid), and remetinostat have demonstrated therapeutic potential in various skin disease models. Therefore, understanding the function and mechanism of HDACs in normal and pathological skin provides a better understanding of skin pathophysiology and new insights into targeted therapies for dermatological diseases.

목차

서 론(Introduction)

정상 피부에서의 HDAC의 발현과 기능

피부 섬유화(Skin Fibrosis)

상처 치유(Wound Healing)

염증(Inflammation)

건선(Psoriasis)

피부 노화(Skin Aging)

기타 질환

결 론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

HDAC Skin Fibrosis Wound healing Inflammation Psoriasis Aging