혈중 IL-6, TNF-α, IGF-1과 영역별 인지기능 저하와의 연관성

• 영문명: The Association of Blood IL-6, TNF-α, and IGF-1 With Domains of Cognitive Impairment
• 발행기관: 대한노인정신의학회
• 저자명: 유가희(Ka Hee Yoo) 손경훈(Kyung Hoon Son) 한재현(Jae Hyun Han) 송주연(Joo Yun Song) 박기정(Kee Jeong Park) 조영탁(Young Tak Jo) 황재연(Jae Yeon Hwang) 성수정(Su Jeong Seong)
• 간행물 정보: 『노인정신의학』제29권 제1호, 9~17쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.04.30

국문 초록

Objective: Neuroinflammation is suggested to play an important role in the pathophysiology of cognitive impairment. The aim of this study was to investigate the correlation between blood levels of biomarkers and cognitive impairment. Methods: We measured the blood levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and insulin-like growth factor-1 (IGF-1) in a sample of community-residing elderly Koreans (n=37). To evaluate cognitive function, we used the Korean version of the Mini-Mental State Examination (MMSE). We analyzed the association between biomarker levels and the total score, as well as the scores for each domain of the MMSE. Results: We excluded the scores in the three-word registration and naming domains of the MMSE from the analysis, because all participants received perfect scores. The results of simple regression analysis revealed that there is a statistically significant association between higher levels of IL-6 and decreased scores in the repetition domain of the MMSE. However, we found no significant association between TNF-α and IGF-1 levels and the scores of cognitive function tests. Conclusion: Our results indicate a potential role of inflammatory cytokines in certain cognitive functions, which requires further exploration.

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키워드

인지저하 인지검사 인터루킨-6 종양괴사인자-알파 인슐린유사성장인자 Cognitive impairment Cognitive test Interleukin-6 Tumor necrosis factor-alpha Insulin-like growth factor