Cancer History and Age-Related Macular Degeneration: Age Appears to be an Influential Factor

• 영문명: Cancer History and Age-Related Macular Degeneration: Age Appears to be an Influential Factor
• 발행기관: 대한임상노인학회
• 저자명: Jae Hyuck Lee In Cheol Hwang Yoo Jeong Lee Hong Yup Ahn
• 간행물 정보: 『대한임상노인학회지』제25권 제2호, 99~104쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2024.08.31

국문 초록

Background: Both cancer and neurodegenerative disease impose significant burden on the daily lives of older adults. Interestingly, previous studies have observed an inverse association between cancer and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. This study evaluated the association between a history of cancer and the prevalence of age-related macular degeneration (AMD), a neurodegenerative disease affecting the retina, among cancer survivors. Methods: Using data from the Korean National Health and Nutrition Examination Survey (KNHANES 2017-2018), we selected the data of 6,993 adults, including 452 cancer survivors, that had received and ophthalmic examination. A multivariate logistic regression model adjusted for potential covariates was used to investigate the association between cancer history and AMD prevalence. Results: Participants with a cancer history were less likely to have AMD, but this relation was not significant. However, age-stratified analysis revealed that the prevalence of AMD tended to be lower only among young cancer survivors aged ＜55 years (P=0.076). Conclusion: An inverse association between cancer and AMD might exist in young individuals. These findings highlight the potential importance of considering age-specific effects in the study of comorbidities between cancer and neurodegenerative diseases. Further research with large sample sizes and longitudinal data is warranted to confirm these observations and elucidate underlying mechanisms.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

FUNDING

CONFLICT OF INTEREST

REFERENCES

키워드

Age-related macular degeneration Cancer survivor Neoplasm Neurodegenerative disease