전염성 생식기 종양 개에서 빈크리스틴 투여 후 ECPKA 수치의 변화

• 영문명: Changes in ECPKA Levels Following Vincristine Administration in a Transmissible Venereal Tumor Dog
• 발행기관: 한국동물보건학회
• 저자명: 한세명
• 간행물 정보: 『한국동물보건학회지』2권 3호, 141~147쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.09.30

영문 초록

A spayed male, Pomeranian, 10-year-old, presented to the veterinary hospital with swelling of the bulbus gland and exudate from the genitals. After general examinations such as complete blood counts, serum chemistry, X-rays and abdominal ultrasounds, fine needle aspiration tests for genital masses were performed. It was diagnosed with infectious genital tumor [Transmissible Venereal Tumor (TVT)] from the test results, vincristine was administered intravenously at a dose of 0.7 mg/m2 at intervals of 1 week and 3 times as a chemotherapy. During chemotherapy, genital masses decreased to normal, and the level of ECPKA(Extracellular cyclic AMP-dependent protein kinase A) before chemotherapy was 1015.08 UI, but one week after the third administration of vincristine, the level decreased significantly to 260.94 UI. ECPKA is very low in normal conditions, but its usefulness in the early detection of tumors in dogs has been suggested in the fact that it can be elevated in tumor tissue. Evaluation of the termination of chemotherapy while proceeding with treatment by checking blood levels such as ECPKA makes it possible to judge tumor remission, and it can be used before and after chemotherapy in various tumors other than TVT.

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ORCID

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키워드

Bulbus gland Dog ECPKA Transmissible venereal tumor Vincristine