Late side effects of bleomycin injection into the lower lip mucosa of a nine-year-old patient with venous malformation

• 영문명: Late side effects of bleomycin injection into the lower lip mucosa of a nine-year-old patient with venous malformation
• 발행기관: 대한구강악안면외과학회
• 저자명: Kezia Rachellea Mustakim Soung Min Kim
• 간행물 정보: 『대한구강악안면외과학회지』제49권 제5호, 304~307쪽, 전체 4쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2023.10.31

영문 초록

Venous malformation (VM) is a benign lesion of blood vessels caused by an error in vascular morphogenesis during the embryologic phase. This entity mostly affects the head and neck region, including the lips, tongue, buccal mucosa, gingiva, or palate. VM may cause functional and aesthetic impairments. The anatomical structure and shape of the lips provide an important aesthetic accent for an individual. Therefore, management of VM in the lip area without postoperative defects or scarring is challenging. In this brief communication article, we present a conservative approach to lip VM in a nine-year-old boy using a bleomycin injection that had good aesthetic and functional outcomes. Injection of 2 mL of 1/10 of 15 mg bleomycin in a saline dilution into the lip mucosa may present a drug reaction as a white plaque and reddish owl eye lesion that takes up to three weeks to resolve without a scar. It is important to recognize the characteristics and self-limiting nature of postoperative bleomycin complications to avoid unnecessary treatment.

목차

Ⅰ. Introduction

Ⅱ. Brief Communication

Ⅲ. Discussion

ORCID

Authors’ Contributions

Funding

Ethics Approval and Consent to Participate

Conflict of Interest

References

키워드

Arteriovenous malformation Bleomycin Drug side effects Pediatrics Sclerotherapy