Allium victorialis leaf extract ameliorates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice

• 발행기관: 한국예방수의학회
• 저자명: Hyeryeon Yang Jong Bae Seong Hyun Sik Yoon Il Rae Rho Du Hyeon Hwang Euikyung Kim Changkeun Kang
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.46, No.2, 68~74쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.06.30

영문 초록

The leaves of Allium victorialis (AV) are known an edible perennial herb, which has been used in Korean traditional medicine. However, the beneficial pharmacological effects of AV extracts (AVE) on the antioxidant activity and atopic dermatitis (AD) have not been thoroughly examined. Therefore, the present study aims to investigate both antioxidant activity and anti-inflammatory effect of AVE on AD in vitro and in vivo. Antioxidant activity was evaluated by total polyphenol content and ferric reducing ability. AVE showed a level of polyphenol content and reducing power activity. The five-week-old BALB/c mice were used as an AD-like mouse model by treating them with 1-chloro-2, 4-dinitrobenzene (DNCB). Topical administration of AVE for 3 weeks to DNCB-treated mice significantly alleviated clinical skin lesion dermatitis severity and epidermal thickness. Histopathological analysis also demonstrated that AVE decreased eosinophil and mast cell infiltration into skin and ear tissue. These results suggest that topical application of AVE inhibits the development of AD-like skin lesion in mice by their antioxidant activity. Thus, AVE may be a potential therapeutic agent for AD.

목차

INTRODUCTION

MATERIALS AND METHODS

Results

DISCUSSION

ACKNOWLEDGMENTS

REFERENCES

키워드

Allium victorialis antioxidant activity atopic dermatitis DNCB treatment