디옥시리보스 1-인산에 의한 멜라닌 생성에 미치는

• 영문명: K+-Cl−-cotransport Mediates the Deoxyribose 1-phosphate-Induced Melanogenesis
• 발행기관: 대한약학회
• 저자명: 이용수(Yong Soo Lee)
• 간행물 정보: 『약학회지』제65권 제5호(2021년), 363~369쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

The effect of deoxyribose 1-phosphate (dRP) on melanogenesis was investigated in B16 melanoma cells. dRP increased both reactive oxygen species (ROS) levels and melanin content in a dose-dependent manner in B16 cells. These effects were significantly reduced by apocynin (Apo) and diphenyleneiodonium (DPI), which are inhibitors of the NADPH oxidase (NOX). DIOA, a blocker of the K+-Cl−-cotransports (KCCs), significantly inhibited dRP-induced activation of KCCs and melanogenesis. The NOX inhibitors(Apo and DPI) also significantly blocked dRP-induced activation of KCCs. Collectively, these results suggest that dRP may activate KCCs through NOX-mediated ROS production, and in turn, induce melanogenesis in B16 cells.

목차

서론(Introduction)

방법(Methods)

결과및고찰(Results and Discussion)

결론(Conclusion)

Conflict of Interest

References

키워드

Deoxyribose 1-phosphate Melanogenesis NADPH oxidase K+-Cl− -cotransport Reactive oxygen species B16melanoma cell