¹H-NMR Spectroscopy를 이용한 Non-ionic Monomer 조영제의 화학적 구조 분석

• 영문명: Chemical Structure Analysis of Non-ionic Monomer Contrast Agents Using ¹H-NMR Spectroscopy
• 발행기관: 대한방사선과학회(구 대한방사선기술학회)
• 저자명: 한범희(Beom-Hee Han)
• 간행물 정보: 『방사선기술과학』방사선기술과학 제44권 제4호, 335~342쪽, 전체 8쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2021.08.30

영문 초록

Studies on the side effects of contrast agents are being discussed based on various cases, but studies analyzing the chemical structure of the underlying contrast agents are difficult to understand as the manufacturers have not disclosed them. Therefore, in this study, the chemical structure of the contrast medium was analyzed using 1H-NMR spectrometer for Omnipaque contrast medium prepared from Iohexol, which is a nonionic iodide contrast medium, Xenetix contrast medium from Iobitridol, and Iomeron contrast medium from Iomeprol. As a result, it was found that the Omnipaque contrast medium of Iohexol had 6 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. It was found that the Xenetix contrast medium of the iobitridol formulation had 6 carboxyl groups, 3 carbonyl groups, 2 amine groups, and 4 cyano groups. It was found that the Iomeron contrast agent of the Iomeprol formulation had 5 carboxyl groups, 3 carbonyl groups, 4 amine groups, 1 methyl group, and 2 cyano groups. As shown in this study, the chemical structure of the non-ionic monomer contrast agent increases its affinity with water by binding a number of hydroxyl groups (OH) to the carboxyl group. It is necessary to accurately identify each of these factors and analyze the physical and chemical changes of the contrast medium according to various environmental factors.

목차

Ⅰ. 서 론

Ⅱ. 대상 및 방법

Ⅲ. 결 과

Ⅳ. 고 찰

Ⅴ. 결 론

REFERENCES

키워드

비이온성단량체조영제 핵자기공명분광법 이오헥솔 이오비트리돌 이오메프롤 Non-ionic Monomer Contrast Agents NMR Iohexol Iobitridol Iomeprol