학술논문
Effects of natural extracts on COX-1 and COX-2 mRNA expression on UVB-induced skin inflammation in C57BL/6 mouse
이용수 7
- 영문명
- 발행기관
- 한국환경보건학회
- 저자명
- Ryoung-Me Ahn
- 간행물 정보
- 『한국환경보건학회지』제32권 제6호, 566~570쪽, 전체 5쪽
- 주제분류
- 공학 > 환경공학
- 파일형태
- 발행일자
- 2006.12.30
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국문 초록
영문 초록
Exposure to ultraviolet B(UVB) radiation causes skin inflammation such as pigmentation and the induction of cyclooxygenase-2(COX-2) gene expression. In this study, we investigated the effect of natural extracts from Tea, EGb 761 and Korean red ginseng(KRG), on the pigmentation and expression of COX-1 and COX-2 mRNA in UVB-irradiated C57BL/6 mice. Before UVB irradiation, the skin color was significantly showed the lightening effect by topical application of natural compounds (p<.05). In the case of UVB irradiated mice, we observed a decrease in pigmentation by compounds (p<.05). In irradiated skin, COX-1 mRNA expression is not changed following UVB irradiation, but COX-2 gene increases. Also, natural compounds lowered mRNA levels of COX-2. Therefore, these results suggest that COX-2 mRNA increases by UVB irradiation. Also, Tea, EGb 761 and KRG as a topical application may inhibit skin pigmentation and modulate COX-2 mRNA level.
목차
Introduction
Materials and Methods
Results
Discussion
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